Michael P Murphy Selected Research

mitoquinone

3/2022	MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity.
3/2022	MitoQ Prevents Human Breast Cancer Recurrence and Lung Metastasis in Mice.
11/2021	Effective therapeutic strategies in a preclinical mouse model of Charcot-Marie-Tooth disease.
1/2021	Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes.
1/2021	Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia.
1/2020	Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss.
1/2020	Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice.
1/2019	The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion.
1/2019	Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.
12/2018	Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model.

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Michael P Murphy Research Topics

Disease

33	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 05/2006
27	Inflammation (Inflammations) 01/2022 - 01/2010
24	Hypoxia (Hypoxemia) 01/2022 - 12/2003
24	Ischemia 01/2022 - 07/2005
23	Reperfusion Injury 01/2022 - 07/2005
17	Neoplasms (Cancer) 03/2022 - 03/2009
11	Alzheimer Disease (Alzheimer's Disease) 12/2020 - 01/2006
8	Obesity 01/2020 - 06/2006
8	Chronic Limb-Threatening Ischemia 01/2018 - 08/2008
7	Necrosis 01/2022 - 07/2005
7	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 08/2009
7	Abdominal Aortic Aneurysm 12/2018 - 09/2012
6	Breast Neoplasms (Breast Cancer) 03/2022 - 09/2010
6	Myocardial Infarction 01/2022 - 06/2013
6	Fibrosis (Cirrhosis) 04/2021 - 10/2012
6	Heart Failure 11/2020 - 04/2010
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2009
6	Stroke (Strokes) 01/2018 - 08/2009
6	Atherosclerosis 12/2017 - 05/2009
6	Parkinson Disease (Parkinson's Disease) 01/2013 - 11/2004
5	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022 - 06/2014
5	Infections 12/2018 - 08/2010
5	Disease Progression 10/2018 - 10/2003
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2016 - 10/2010
4	Sepsis (Septicemia) 01/2021 - 04/2006
4	Hyperglycemia 11/2020 - 02/2004
4	Insulin Resistance 01/2020 - 01/2012
4	Type 2 Diabetes Mellitus (MODY) 01/2019 - 01/2011
4	Infarction (Infarctions) 01/2018 - 03/2013
4	Body Weight (Weight, Body) 11/2017 - 01/2012
4	Peripheral Arterial Disease 04/2017 - 08/2008
4	Fatty Liver 10/2015 - 08/2010
4	Hypertension (High Blood Pressure) 03/2014 - 05/2007
3	Wounds and Injuries (Trauma) 01/2022 - 11/2013
3	Cardiomyopathies (Cardiomyopathy) 01/2021 - 12/2019
3	Thrombosis (Thrombus) 10/2020 - 01/2018
3	Acute Kidney Injury (Acute Renal Failure) 10/2020 - 08/2015
3	Memory Disorders (Memory Loss) 01/2020 - 04/2011
3	Brain Injuries (Brain Injury) 01/2020 - 06/2006
3	Pathologic Constriction (Stenosis) 01/2019 - 01/2018
3	Pain (Aches) 01/2018 - 01/2016
3	Myocardial Ischemia (Ischemic Heart Diseases) 01/2018 - 03/2016
3	Atherosclerotic Plaque (Atheroma) 12/2017 - 03/2012
3	Glucose Intolerance 04/2016 - 10/2010
2	Neoplasm Metastasis (Metastasis) 03/2022 - 03/2022
2	Edema (Dropsy) 01/2022 - 01/2018
2	Tuberculosis (Tuberculoses) 01/2022 - 10/2014

Drug/Important Bio-Agent (IBA)

51	AntioxidantsIBA 03/2022 - 10/2003
43	mitoquinoneIBA 03/2022 - 07/2005
42	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 02/2004
17	Superoxides (Superoxide)IBA 03/2022 - 04/2006
17	Succinic Acid (Succinate)IBA 01/2022 - 11/2014
17	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2005
13	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 02/2004
13	Mitochondrial DNA (mtDNA)IBA 10/2020 - 12/2006
12	Oxygen (Dioxygen)IBA 03/2022 - 12/2003
11	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2022 - 04/2005
8	Adenosine Triphosphate (ATP)IBA 01/2021 - 06/2006
8	Mitochondrial Proteins (Mitochondrial Protein)IBA 12/2018 - 10/2003
7	Biomarkers (Surrogate Marker)IBA 02/2021 - 12/2008
7	CytokinesIBA 01/2021 - 08/2013
6	Lactic Acid (Lactate)FDA LinkGeneric 01/2022 - 10/2010
5	LipidsIBA 01/2021 - 09/2007
4	Pharmaceutical PreparationsIBA 03/2022 - 10/2014
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 07/2005
4	Anti-Bacterial Agents (Antibiotics)IBA 11/2021 - 04/2009
4	Amyloid beta-PeptidesIBA 12/2020 - 01/2006
4	EnzymesIBA 01/2020 - 05/2006
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 06/2006
4	Oxidants (Oxidizing Agents)IBA 01/2020 - 08/2008
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 01/2006
4	Apolipoproteins E (ApoE)IBA 12/2017 - 10/2010
4	S-NitrosothiolsIBA 01/2017 - 06/2009
3	Cysteine (L-Cysteine)FDA Link 01/2022 - 06/2013
3	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2022 - 11/2014
3	ProdrugsIBA 01/2022 - 08/2008
3	Pyruvic Acid (Pyruvate)IBA 01/2022 - 07/2017
3	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 08/2015
3	Pyruvaldehyde (Methylglyoxal)IBA 04/2021 - 02/2014
3	Transcription Factors (Transcription Factor)IBA 01/2019 - 09/2012
3	Drinking WaterIBA 12/2018 - 08/2009
3	ApolipoproteinsIBA 01/2018 - 10/2010
3	NAD (NADH)IBA 01/2018 - 10/2014
3	Sulfhydryl Compounds (Thiols)IBA 01/2017 - 06/2009
3	triphenylphosphoniumIBA 10/2016 - 06/2013
3	Superoxide DismutaseIBA 03/2015 - 05/2006
3	InflammasomesIBA 02/2014 - 05/2012
3	3-nitrotyrosineIBA 08/2013 - 07/2011
2	malonic acid (malonate)IBA 01/2022 - 01/2020
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 09/2012
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2022 - 12/2018
2	EstersIBA 01/2022 - 01/2020
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2015

Therapy/Procedure

37	Therapeutics 01/2022 - 11/2005
7	Cell- and Tissue-Based Therapy (Cell Therapy) 11/2020 - 04/2009
7	Surgical Amputation (Amputations) 01/2018 - 08/2008
5	Stents 10/2020 - 01/2018
5	Endovascular Aneurysm Repair 05/2019 - 10/2012
4	Transplantation 01/2018 - 04/2010
3	Ligation 11/2013 - 08/2008